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The molecule was developed from the screening of a large number (more than 190) of anti-miR-17 oligonucleotides from which it was found to be specific for inhibiting ADPKD

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For instance, comparison of the cytotoxicity of positively and negatively charged Au NPs revealed that the positively charged NPs were more toxic, due to their enhanced uptake (Huhn et al., 2013)