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Receptordependent effects of melatonin in GC: The suppression of the NF-B pathway (reduced p-p65), accompanied by downregulation of cyclin D1, MMP2, MMP9, and Bcl-2, may involve receptor-mediated signaling, since melatonin receptors are expressed in GI tissue

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The failure of vascular support eventually results in decreased production of progesterone and the involution of the luteal tissue